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中枢神经系统炎性脱髓鞘患者血清AQP-4抗体与细胞因子的研究
作者:杨扬        黄德晖        吴卫平 
单位:中国人民解放军总医院神经内科 100850 
关键词:视神经脊髓炎      多发性硬化      AQP-4抗体      干扰素-γ      白细胞介素-4 
分类号:R744.5+1 R744.5+2
出版年,卷(期):页码:2010,17(2):101-103
摘要:

目的 研究中枢神经系统炎性脱髓鞘疾病患者血清水通道蛋白(AQP-4)抗体、细胞因子干扰素-γ(IFN-γ)及白细胞介素-4(IL-4)水平,以及AQP-4抗体与IFN-γ和IL-4间的相关性,探讨视神经脊髓炎(NMO)和多发性硬化(MS)的发病机制.方法 入选患者共130例,其中NMO患者41例,MS患者59例,临床孤立综合征(CIS)患者15例,其他神经系统疾病患者15例.采用细胞转染的间接免疫荧光法检测患者血清AQP-4抗体滴度,ELISA法检测患者血清IFN-γ和IL-4水平,比较各组患者血清AQP

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