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髓鞘少突胶质细胞糖蛋白抗体在多发性硬化中的意义
作者:夏君慧        张旭        XIA Jun-hui        ZHANG Xu 
单位:温州医学院附属第一医院神经科 浙江 温州 325000 
关键词:多发性硬化      髓鞘少突胶质细胞糖蛋白      抗体 
分类号:R744.5
出版年,卷(期):页码:2008,15(6):0-0
摘要:
目的 探讨髓鞘少突胶质细胞糖蛋白(MOG)抗体与多发性硬化(MS)临床表现及复发缓解型MS(RRMS)复发的关系.方法 采用酶联免疫吸附法(ELISA)对60例MS、23例其他炎性神经疾病(OIND)、29例非炎性神经疾病(NIND)以及50例神经系统正常的对照(NC)患者血清及脑脊液(CSF)MOG抗体进行检测.结果 MS患者CSF MOG抗体阳性率为28.3%(17/60),明显高于NC组[2%(1/50)]和NIND组[0%(0/29)],但与OIND组[21.7%(5/23)]比较差异无统计学意义.各组血清MOG抗体均为阴性.抗体阳性率急性活动期为31.8%(14/44),与稳定期[18.75%(3/16)]比较差异无统计学意义.CSF MOG抗体阳性的RRMS患者复发时间早于阴性患者,且其第1,2年复发率均高于阴性患者.结论 在部分MS患者中枢神经系统内存在异常的MOG特异性B细胞免疫应答,且CSF MOG抗体对RRMS的复发有一定预测作用.
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参考文献:
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