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PPARγ激动剂与小胶质细胞和中枢神经系统炎症变性疾病的关系
作者:项正兵        吴晓牧 
单位:江西省人民医院神经内科 南昌 330006 
关键词:过氧化物酶体增殖物活化受体γ      小胶质细胞      阿茨海默病      帕金森病      多发性硬化 
分类号:R741.02
出版年,卷(期):页码:2007,14(6):0-0
摘要:
过氧化物酶体增殖物活化受体γ(PPARγ)是一种核转录因子,属由配体激活的Ⅱ型核受体超家族的成员.PPARγ除参与脂质代谢、胰岛素抵抗、脂肪细胞分化、动脉粥样硬化和肿瘤生成外,还参与炎症反应及免疫调节.PPARγ激动剂能通过PPARγ依赖或非依赖机制抑制活化的小胶质细胞、保护神经元、促进活化的小胶质细胞凋亡从而控制中枢神经系统(CNS)炎症变性疾病如阿茨海默病(AD)、帕金森病(PD)和多发性硬化(MS).提示PPARγ激动剂有可能成为一类很有治疗CNS炎症性及退行性变性疾病前景的药物.
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参考文献:
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