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晚期糖基化终产物及其受体在糖尿病周围神经病变中的作用
作者:陆邦超        王坚 
单位:南京军区南京总医院内分泌科 江苏 南京210002 
关键词:晚期糖基化终产物      糖尿病周围神经病变 
分类号:R745
出版年,卷(期):页码:2007,14(6):0-0
摘要:
该文概述了晚期糖基化终产物(AGEs)及其受体在周围神经组织中的表达与分布及其在糖尿病周围神经病变(DPN)中的作用.AGEs及其受体在DPN中的可能作用机制研究有望为开发预防、治疗DPN的新药提供理论基础.
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参考文献:
潘晓东.陈晓春 非酶糖化、晚期糖基化终产物与阿尔茨海默病 [期刊论文] -国际神经病学神经外科学杂志2005 Kikuchi S.Shinpo K.Takeuchi M Glycation-a sweet tempter for neuronal death 2003 Stracke H.Hammes HP.Werkmann D Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats 2003 Haslbeck KM.Schleicher ED.Friess U N(epsilon)-Carboxy-methyllysine in diabetic and non-diabetic polyneuropathies 2002 Wada R.Nishizawa Y.Yagihashi N Effects of OPB-9195,anti-glycation agent,on experimental diabetic neuropathy 2001 Poirier O.Nicaud V.Vionnet N Polymorphism screening of four genes encoding advanced glycation end-product putative receptors.Association study with nephropathy in type 1 diabetic patients 2001 Takeuchi M Neurotoxicity of advanced glycation end-products for cultured cortical neurons 2000 Sekido H.Suzuki T.Jomori T Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells 2004 Bierhaus A.Schiekofer S.Schwaninger M Diabetes-associated sustained activation of the transcription factor nuclear factorκB 2001 Flatters SJ.Fox AJ.Dickenson AH Nerve injury alters the effects of interleukin-6 on nociceptive transmission in peripheral afferents 2004 Brownlee M Biochemistry and molecular cell biology of diabetic complications 2001 Angelika B.Karl-Matthias H.Per MH Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily 2004
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