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脑缺血小鼠额叶皮层和海马组织cAMP水平的变化
作者:王伟斌        宋春风        吕佩源        尹昱        粱翠萍        WANG Wei-bin        SONG Chun-feng        LU Pei-yuan        YIN Yu        LIANG Cui-ping 
单位:王伟斌 吕佩源 尹昱 粱翠萍 WANG Wei-bin LU Pei-yuan YIN Yu LIANG Cui-ping(河北省人民医院神经内科 河北 石家庄 050051)宋春风 SONG Chun-feng(河北医科大学电镜实验中心 河北 石家庄 050017) 
关键词:脑缺血      环磷酸腺苷      放射免疫法 
分类号:R749.1
出版年,卷(期):页码:2005,12(6):0-0
摘要:
目的观测缺血性小鼠额叶皮层和海马组织环磷酸腺苷(cAMP)水平,探讨脑缺血发病的分子生物学机制.方法通过双侧颈总动脉线结、连续3次缺血-再灌注制作脑缺血动物模型,并设立假手术组;术后29、30 d分别测试学习和记忆成绩;应用放射免疫法检测小鼠额叶皮层和海马组织cAMP水平.结果与假手术组比较,模型组学习和记忆成绩均降低(P<0.05),且额叶皮层和海马组织cAMP水平也降低(P<0.05).结论额叶皮层和海马组织cAMP水平降低可能参与了脑缺血的分子生物学发病机制.
bioclavid norge fabrikantimmunitet.site bioclavid modic
基金项目:
河北省自然科学基金
作者简介:
参考文献:
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