中国神经免疫学和神经病学

脑缺血小鼠额叶皮层和海马组织cAMP水平的变化

作者：王伟斌宋春风吕佩源尹昱粱翠萍 WANG Wei-bin SONG Chun-feng LU Pei-yuan YIN Yu LIANG Cui-ping

单位：王伟斌吕佩源尹昱粱翠萍 WANG Wei-bin LU Pei-yuan YIN Yu LIANG Cui-ping(河北省人民医院神经内科河北石家庄 050051)宋春风 SONG Chun-feng(河北医科大学电镜实验中心河北石家庄 050017)

关键词：脑缺血环磷酸腺苷放射免疫法

分类号：R749.1

出版年,卷(期):页码：2005,12(6):0-0

摘要：

目的观测缺血性小鼠额叶皮层和海马组织环磷酸腺苷(cAMP)水平,探讨脑缺血发病的分子生物学机制.方法通过双侧颈总动脉线结、连续3次缺血-再灌注制作脑缺血动物模型,并设立假手术组;术后29、30 d分别测试学习和记忆成绩;应用放射免疫法检测小鼠额叶皮层和海马组织cAMP水平.结果与假手术组比较,模型组学习和记忆成绩均降低(P＜0.05),且额叶皮层和海马组织cAMP水平也降低(P＜0.05).结论额叶皮层和海马组织cAMP水平降低可能参与了脑缺血的分子生物学发病机制.

基金项目：

河北省自然科学基金

作者简介：

参考文献：

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