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Charcot-Marie-Tooth病Ⅰ型的免疫学机制研究进展(综述)
作者:笪宇威        贾建平 
单位:首都医科大学宣武医院神经内科 北京 100053 
关键词:Charcot-Marie-Tooth病      免疫机制 
分类号:R744.5 R746
出版年,卷(期):页码:2005,12(6):0-0
摘要:
Charcot-Marie-Tooth病(CMT)即进行性腓骨肌萎缩症,是神经系统常见的遗传病之一,目前已报道11个致病基因与Ⅰ型相关.近来研究发现,CMT1(脱髓鞘型)动物模型中髓鞘损害伴随T淋巴细胞和巨噬细胞增加,部分CMT患者周围血中活化的T细胞增加,MHC-Ⅱ分子在腓肠神经中表达增高以及一些病例对激素治疗效果好,均提示该病可能与免疫因素有关.
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参考文献:
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