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纤维蛋白原β基因148C/T及亚甲基四氢叶酸还原酶基因677C/T多态性与脑梗死的关系研究
作者:李永杰        霍阳        高旭光        滕智平        任正洪        潘凯枫        LI Yong-jie        HUO Yang        GAO Xu-guang        TENG Zhi-ping        REN Zheng-hong        PAN Kai-feng 
单位:李永杰 霍阳 高旭光 LI Yong-jie HUO Yang GAO Xu-guang(北京大学人民医院神经内科 北京 100044)滕智平 TENG Zhi-ping(北京大学人民医院血液科 北京 100044)任正洪 REN Zheng-hong(北京大学医学部公共卫生学系 北京 100083)潘凯枫 PAN Kai-feng(北京大学肿瘤防治研究所流行病室 北京 100034) 
关键词:脑梗死      纤维蛋白原β基因      亚甲基四氢叶酸还原酶基因      多态性 
分类号:R743
出版年,卷(期):页码:2005,12(6):0-0
摘要:
目的探讨纤维蛋白原(Fg)β基因148(β148)C/T及亚甲基四氢叶酸还原酶基因(MTHFR)677C/T多态性与脑梗死易感性的关系.方法按年龄、性别、有无高血压病史及糖尿病史选取相匹配的病例组及对照组各100例,利用聚合酶链反应-变性高效液相色谱法(PCR-DHPLC)确定Fgβ148及MTHFR 677基因型.结果大动脉粥样硬化组(TOAST分型)及相应对照组Fgβ148 CC、CT/TT基因型分布差异有显著性(P=0.035),余各组两个多态位点的基因型分布差异无显著性.吸烟或饮酒的Fgβ CT/TT基因型携带者在病例组和对照组的分布差异有显著性(均P<0.05).结论Fgβ148 CT/TT基因型可能是大动脉粥样硬化性脑梗死的危险因素,携带FgβCT/TT基因型同时吸烟或饮酒可能是脑梗死的危险因素.
基金项目:
卫生部科研项目
作者简介:
参考文献:
Kelly PJ.Rosand J.Kistler JP Homocysteine,MTHFR 677C->T polymorphism,and risk of ischemic stroke:results of a meta-analysis 2002(04) Wilhelmsen L.Svardsudd K.Korsan-Bengtsen K Fibrinogen as a risk factor for stroke and myocardial infarction 1984(08) Adams HP Jr.Bendixen BH.Kappelle LJ Classification of subtype of acute ischemic stroke.Definitions for use in a multicenter clinical trial,TOAST Trial of Org 10172 in Acute Stroke Treatment 1993(01) Li Z.Sun L.Zhang H Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke,but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke:a M ulticenter Case-Control Study in China 2003 吕波.赵斌.邢永前 脑梗死患者纤维蛋白原β148 C/T基因多态性的研究 [期刊论文] -临床神经病学杂志2003(04) Parnetti L.Caso V.Santucci A Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke 2004(01) Humphries SE.Luong LA.Montgomery HE Gene-environment interaction in the determination of levels of plasma fibrinogen 1999(02) Blake GJ.Schmitz C.Lindpaintner K Mutation in the promoter region of the beta-fibrinogen gene and the risk of future myocardial infarction,stroke and venous thrombosis 2001(24) Schmidt H.Schmidt R.Niederkorn K Beta-fibrinogen gene polymorphism (C148->T) is associated with carotid atherosclerosis:results of the Austrian stroke prevention study 1998(03) Kelly PJ.Rosand J.Kistler JP Homocysteine,MTHFR 677C->T polymorphism,and risk of ischemic stroke:results of a meta-analysis 2002(04) Eikelboom JW.Hankey GJ.Anand SS Association between high homocyst (e)ine and ischemic stroke due to large-and small-artery disease but not other etiologic subtypes of ischemic stroke 2000(05) Zhang G.Dai C Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases 2001(03) 施锦绣.杨爽.姜正文 变性高效液相色谱与直接测序法在单核苷酸多态性检测中的应用比较 [期刊论文] -中华医学遗传学杂志2001(03)
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