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EAE大鼠中枢神经系统与外周免疫器官细胞凋亡的研究
作者:陈慧芳        吕佩源        陈竞清        林嘉友 
单位:陈慧芳 吕佩源(河北省人民医院神经内科 河北 石家庄 050051)陈竞清(河北医科大学第三医院骨科 河北 石家庄 050053)林嘉友(中国医学科学院 中国协和医科大学基础医学研究所神经免疫室 北京 100005) 
关键词:实验性自身免疫性脑脊髓炎      外周免疫器官      细胞凋亡 
分类号:R744.5
出版年,卷(期):页码:2004,11(5):0-0
摘要:
目的比较实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)大鼠中枢神经系统(CNS)与外周免疫器官中细胞的凋亡情况.方法建立EAE大鼠模型,于病程不同阶段取脊髓与外周免疫器官通过脱氧核糖核苷酸末端转移酶介导的缺口末端标记(TUNEL)技术检测细胞凋亡情况.结果脊髓中细胞凋亡现象具有明显的时程特异性,凋亡细胞主要为淋巴细胞、巨噬细胞和小胶质细胞;脾和淋巴结中TUNEL阳性细胞数目均较少,且组内与组间差异均无显著性.结论 EAE外周免疫器官与CNS中不同的环境因素可能直接影响浸润细胞的凋亡状况.
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基金项目:
河北省卫生厅科研项目
作者简介:
参考文献:
Petry KG.Boullerne AI.Pousset F Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis 2000(01) Tabi Z.McCombe PA.Pender MP Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T cells in the central nervous system 1995(06) Pender MP Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance 1999(03) Suvannavejh GC.Dal Canto MC.Matis LA Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis 2000(02) Pender MP.Rist MJ Apoptosis of inflammatory cells in immune control of the nervous system:role of glia 2001(02) White CA.McCombe PA.Pender MP The roles of Fas, Fas ligand and Bcl-2 in T cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis 1998(01) Ishigami T.White CA.Pender MP Soluble antigen therapy induces apoptosis of autoreactive T cells pre ferentially in the target organ rather than in the peripheral lymphoid organs 1998(05) Ayalon S.Brenner T Effects of porphyromonas gingivalis on the central nervous system:activation of glial cells and exacerbation of experimental autoimmune encephalomyelitis 2002(05) 王惠.林嘉友.杨天祝 实验性变态反应性脑脊髓炎与细胞凋亡 [期刊论文] -中国神经免疫学和神经病学杂志2000(03) Engelhardt B Role of glucocorticoids on T cell recruitment across the blood-brain barrier 2000(z2) Nguyen KB.McCombe PA.Pender MP Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone 1997(01)
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