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雌激素对帕金森病保护作用的实验研究
作者:李雪莉        孙圣刚        李红戈        童萼塘 
单位:华中科技大学同济医学院附属协和医院神经内科 湖北 武汉 430022 
关键词:帕金森病      雌激素      保护作用      凋亡 
分类号:R742.5
出版年,卷(期):页码:2003,10(4):0-0
摘要:
目的探讨雌激素对帕金森病是否具有保护作用.方法利用免疫组化染色(ABC)法计数酪氨酸羟化酶(TH)的阳性细胞数,用TUNEL法观察每视野下凋亡细胞的数目,比较各组的差异.结果正常雌性小鼠造模(A)组比去势后造模(B)组中只给予生理盐水(B1)组、造模后去势(C)组中只给予生理盐水(C1)组的TH阳性细胞数目多,凋亡细胞数目少(P<0.05);B1组与C1组差异无显著性(P>0.05);B2组(B组中给予雌激素组)比B1组及C2组(C组中给予雌激素组)比C1组TH阳性细胞多,凋亡细胞数目少(P<0.05).结论雌激素对帕金森病具有保护作用和损伤修复作用,且与凋亡有关.
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