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神经营养因子的两类受体:Trks及p75(综述)
作者:杨卫红        林敬明 
单位:杨卫红(第一军医大学附属珠江医院神经内科 广东 广州 510282)林敬明(第一军医大学附属珠江医院药剂科 广东 广州 510282) 
关键词:Trks      p75      神经营养因子 
分类号:R338
出版年,卷(期):页码:2002,9(4):0-0
摘要:
此文简要回顾了神经营养因子的两类受体--酪氨酸激酶受体家族(Trks)及p75的分子结构、分布、相互作用,与神经营养因子的结合及其后的信号传导路径.
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参考文献:
Levi-Montalcini R The saga of the nerve growth factor 1998(9) Chao MV.Hempstead BL p75 and Trk:a two-receptor system 1995 Friedman WJ.Greene LA Neurotrophin signaling via Trks and p75 1999(1) MacPhee I.Barker PA Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation 1999 Stephens RM.Loeb DM.Copeland TD Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses 1994(3) Hadari YR.Kouhara H.Lax I Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation 1998(7) Xu H.Lee KW.Goldfarb M Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins 1998(29) Qian X.Riccio A.Zhang Y Identification and characterization of novel substrates of Trk receptors in developing neurons 1998 Holgado-Madruga M.Moscatello DK.Emlet DR Grb2-associated binder-1 mediates phosphatidy-linositol 3-kinase activation and the promotion of cell survival by nerve growth factor 1997 York RD.Yao H.Dillon T Rap1 mediates sustained MAP kinase activation induced by nerve growth factor 1998(6676) Mardy S.Miura Y.Endo F Congenital insensitivity to pain with anhidrosis: Novel mutations in the TRKA(NTRK1) gene encoding a high-affinity receptor for nerve growth factor 1999(64) Khursigara G.Orlinick JR.Chao MV Association of the p75 neurotrophin receptor with TRAF6 1999(5) Casaccia-Bonnefil P.Carter BD.Dobrowsky RT Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 1996(6602) Barrett GL The p75 neurotrophin receptor and neuronal apoptosis 2000(2) Ladiwala U.Lachance C.Simoneau SJ p75 neurotrophin receptor expression on adult human oligodendrocytes:signaling without cell death in response to NGF 1998(4) Mahadeo D.Kaplan L.Chao MV High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors 1994(9)
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