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实验性变态反应性脑脊髓炎T淋巴细胞增殖和肿瘤坏死因子- α变化的意义
作者:吕佩源        宋春风        高昌星        井上敦 
单位:吕佩源(河北省人民医院神经内科 )宋春风(河北医科大学电镜实验中心 )高昌星 井上敦(日本信州大学附属病院第三内科) 
关键词:多发性硬化      实验性变态反应性脑脊髓炎      T淋巴细胞增殖      肿瘤坏死 因子-α 
分类号:R744.5+1
出版年,卷(期):页码:2001,8(4):0-0
摘要:
目的探讨实验性变态反应性脑脊髓炎(EAE)T淋巴细胞增殖和肿瘤坏死因子(TNF)-α变化的意义.方法观察Le wis大鼠主动免疫性EAE临床症状、T淋巴细胞增殖以及血清 TNF -α水平. 结果 EAE临床发病过程中,T淋巴细胞增殖活跃,血清 TNF-α水平异常升高,并与临床症状呈正相关. 结论研究表明:EAE时, T淋巴细胞增殖旺盛和 TNF-α生成增多,进而导致血脑屏障的破坏,炎细胞浸润,从而诱发EAE.
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参考文献:
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